ABC Proteins From Bacteria to Man

The first and definitive work on one of the largest families of proteins, the ABC proteins! ATP-binding cassette (ABC) proteins exists in all living organisms and form one of the largest superfamilies. They are integral to almost every biological process and physiological system. Most are involved in the transport of an enormous variety of substances across cell membranes, from small ions to large polypeptides. Many of these proteins are of considerable medical importance. Mutations in several abc-genes lead to genetic diseases, such as cystic fibrosis, Tangier disease and adrenoleukodystrophy, while others play crucial roles in immune responses, cholesterol homeostasis, potassium transport and the regulation of insulin secretion. Yet other ABCs are of major significance in resistance to antibiotics and antifungals, to herbicides in plants, to antimalarial agents, and provide a serious obstacle to chemotherapy in man. With the amount of information on this rapidly expanding group of proteins increasing exponentially, this book is essential for anyone trying to stay abreast of the latest findings in this area of research, as well as those with an interest in experimantal therapeutics, clinical and cell biology, molecular biology, biochemistry, protein chemistry, structural biology, cancer chemotherapy, genetics and microbiology. Written by leading scientists in the field in an accessible style, and including full color throughout, this volume is set to become the gold standard for ABC proteins. Key Features * Phylogeny and Evoloution of ABC Transporters * Fundamental Aspects of the Mechanism of Action of ABC Transporters * Prokaryote ABC Transporters * Non-Mammalian Transporters * Multidrug Transporters * ABC Transporters, Physiological Roles and Human Disease * Full color throughoutHolland, I. Barry is the author of 'ABC Proteins From Bacteria to Man' with ISBN 9780123525512 and ISBN 0123525519.